Use of hydroxychloroquine in pregnancy and lactation – a review of the literature
Medical Review (Med. pregled), 2025, 61(6), 68-72.
R. Gancheva1, A. Kundurdzhiev2, P. Yankova3
1 Medical Faculty, Sofia University Sv. Kliment Ohridski
2 Clinic of Nephrology, University Hospital Sv. Ivan Rilski – Sofia
3 Clinic of Clinical Immunology, University Hospital Alexandrovska – Sofia
Abstract. Hydroxychloroquine is a treatment for rheumatic diseases. It is considered safe during pregnancy and is preferred over the use of systemic corticosteroids. Continued use during pregnancy and lactation is recommended. Treatment with hydroxychloroquine is not associated with an increased risk of birth defects, miscarriages, fetal death, prematurity and reduced number of live births in patients with autoimmune diseases.
Key words: hydroxychloroquine; pregnancy; lactation; safety
Address for correspondence: Rada Gancheva, MD, e-mail: rada_ga@mail.bg