Investigation of paraneoplastic autoantibodies directedagainst intracellular neural antigens in patients with unspecified neurological symptoms
Medical Review (Med. pregled), 2024, 60(3), 33-38.
J. Arabadjiev1, D. Kyurkchiev2
1 Clinic of Medical Oncology, University Hospital Acibadem City, Clinic Tokuda – Sofia
2 Department of Clinical Immunology, Medical Faculty, Medical University Sofia, Clinical Immunology Laboratory, University Hospital Sv. Ivan Rilski – Sofia
Abstract. Cell death is a key process in tissue homeostasis. Approximately between 50 and 70 billion cells die in human body daily. Cell death is divided into programmed or non-programmed, and according to the causes of the immune response – into im¬munogenic and non-immunogenic. The tumor system is a place with excessive intensity of the process of programmed cell death, often due to the ability of the “cleansing systems” of the organism which leads to retention and alteration of its own structure, which is transformed into autoantigens, products of cell death. The interaction of cells in the tumor system with the immune response – dendritic cells, T helpers and B lymphocytes – often results in formation of antibodies directed against their own structure – autoantibodies. Under the influence of the tumor system, para¬neoplastic autoantibodies, related to paraneoplastic syndrome, are generated. The aim of our study was to investigate the presence of paraneoplastic autoantibodies in patients with unclear and undetermined neurological symptoms, presumable the presence of these autoantibodies would provide a potential opportunity for fast and early diagnosis of malignant diseases.
Key words: paraneoplastic antibodies, paraneoplastic syndrome, intracellular neural antigens, tumors
Address for correspondence: Assoc. Prof. Jeliazko Arabadjiev, MD, PhD, е-mail: jarabadjiev@gmail.com