A rare case of hereditary angioedema type I combined with IgE-mediated urticariaand angioneurotic edema
General Medicine, 2025, 27(1), 30-35.
S. Dermendzhiev1,2, P. Deleva1, P. Paskalev1,2, T. Dermendzhiev4, G. Kavlakov1, N. Dimitrova1,2, I. Kolev3,
F. Stoev3
1 Department of Occupational Diseases, Clinical Allergology and Toxicology, Medical University – Plovdiv
2 Department of Occupational Diseases incl. Clinical Allergology Activity, UMHAT “Sv. Georgi” ‒ Plovdiv
3 Medical Faculty, Medical University – Plovdiv
4 Department of Diagnostic and Interventional Radiology, University Hospital Leipzig ‒ Leipzig, Germany
Abstract. Hereditary angioedema is an inherited immune deficiency of the complement system. At the same time, it is a rare disease. Type I has autosomal-dominant inheritance and can define the quantitative deficiency of C1-esterase inhibitor (C1 INH) while in type II the level of C1-esterase inhibitor is normal or even increased but the latter is functionally defective. The pathogenesis of the condition is non-allergic and is not related to IgE-mediated reaction. This, however, does not rule out the possibility of a combination of the two allergic conditions. A similar clinical case, in which we diagnosed a rarely seen in clinical practice combination of HAE with two allergic conditions – angioedema and urticarial, is presented. The description of the case would contribute to a more thorough research of the association of HAE with allergic conditions, it would improve the diagnosis, treatment and quality of life of the patients suffering from these two conditions.
Key words: hereditary angioedema, C1-esterase inhibitor, urticaria, angioneurotic edema
Address for correspondence: Pеtya Deleva, e-mail: petya.deleva@yahoo.com