Synchronous primary tumorsof the endometrium and ovary: a retrospective single-center study
Bulgarian Medical Journal, 2024, 18(4), 42-50.
T. Semova1,4, D. Dimitrov1,4, N. Hinkova2,4, M. Vasileva3,4, E. Petkova2
1 Department of Obstetrics and Gynecology, Faculty of Medicine, Medical University – Pleven
2 Department оf Midwifery, Faculty of Healthcare, Medical University – Pleven
3 Department of Radiology, Faculty of Medicine, Medical University – Pleven
4 UMHAT „Sveta Marina“ – Pleven
Abstract. Introduction: Synchronous endometrial and ovarian tumors are found in approximately 5% of patients with endometrial cancer and 10% of patients with ovarian cancer. Aim: To evaluate the incidence of synchronous endometrial and ovarian tumors in patients who underwent surgery for ovarian cancer, as well as to examine characteristics such as age, histological type of the tumor, grading, stage and adjuvant therapy. Materials and Methods: This retrospective study included 30 patients with histologically proven synchronous endometrial and ovarian carcinomas treated at the „Sveta Marina” University Hospital – Pleven, for the period from February 2016 to March 2023. The specimens were histopathologically examined by two different pathologists at the „Sveta Marina” University Hospital – Pleven, according to the Young and Scully criteria. Data was entered and processed using IBM SPSS Statistics 19.0. Results: The most common histological type of endometrial carcinoma was the endometrioid adenocarcinoma (70%), followed by serous adenocarcinoma (23.3%) and the rarest incidence was that of clear cell carcinoma (3.3%) and mixed endometrioid and clear cell carcinoma (13.3%). In 53.3% endometrial carcinoma was well-differentiated, in 30% it was poorly differentiated and the rarest was the moderately differentiated carcinoma in 16.7% of them. Regarding the histological type of ovarian carcinoma, the most common was that of endometrioid adenocarcinoma (60%), followed by high-grade serous carcinoma (23.3%) and low-grade serous carcinoma (13.3%), and the least common was clear cell carcinoma (3.3%). In 53.3% patients, cancer was well-differentiated, in 30% it was poorly differentiated and in 16.7% it was moderately differentiated. The high percentage of coincidences between the histological type of both carcinomas and their differentiation should be noted. Conclusion: We believe that the introduction of molecular methods in the routine diagnosis of synchronous tumors will become an important diagnostic and prognostic tool and will allow to finally discriminate synchronous tumors from metastatic ones.
Key words: synchronous tumors, endometrial cancer, ovarian cancer
Address for correspondence: Dimitar Dimitrov, MD, е-mail: dr_dimitrov@abv.bg, https://orcid.org/0009-0008-5992-5530