Gut microbiota and bronchial asthma
Bulgarian Medical Journal, 2025, 19(1), 7-10.
E. Stankova, I. Altankova, A. Kukov, R. Vazharova, A. Goncharov, T. Todorov, A. Syarov, I. Ivanova, Y. Uzunova
University Hospital “Lozenetz”, Medical Faculty, Sofi a University “Sv. Кliment Ohridski” – Sofia
Abstract. Bronchial asthma (BA) is the most common chronic disease in childhood, with a global trend of increasing morbidity and mortality over the last 40 years. New genomic sequencing technologies have enriched our knowledge of the human microbiota, in particular the gut microbiota, and have made it possible to demonstrate that disruption of the balance between the microbiota and the host leads to disruptions in the immune system associated with immunological intolerance and the onset of atopic diseases, including BA. Future and more detailed study of the microbiota and the mechanisms underlying its development will allow more eff ective approaches to the prevention and treatment of BA.
Key words: asthma, gut microbiome, microbiota