Type I and Type III-interferon response of SARS-CoV-2 infected cell
Medical Review (Med. pregled), 2024, 60(3), 12-21.
T.Valkov1,2
1 Dept. оf Infectious Diseases, Parasitology and Tropical Medicine, Medical Faculty, Medical University – Sofia
2 Specialized Hospital for Active Treatment of Infectious and Parasitic Diseases „Prof. I. Kirov“ – Sofia
Abstract. SARS-CoV-2 causing COVID-19 pandemics, is a respiratory RNA-containing virus, still a serious problem for health systems. According WHO so far over 770 milion have been infected and over 7 milion lost their lives. The course of SARS-CoV-2 infection demonstrates a wide clinical spectrum – from asymptomatic to mild res-piratory symptomatic up to severe clinical picture with acute respiratory distress. Interferons type I and type III are proinflammatory cytokines responsible for the primary cell defence against viruses. Similarly to other viruses, SARS-CoV-2 has elaborated evolutionary mechanisms allowing blocking of interferons” antiviral effect at different levels of infection. A review of these mechanisms is the aim and subject of the current paper.
Key words: SARS-CoV-2, interferon type I, interferon type III, mechanisms blocking the anti-viral effects of interferons
Address for correspondence: Trifon Valkov, MD, e-mail: trifon_heim@abv.bg