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Association of 13q14 deletion with clinico-laboratory parameters in B-cell chronic lymphocytic leukemia (B-CLL)

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dc.contributor.author Hadzhiev, E.
dc.contributor.author Alexandrova, K.
dc.contributor.author Velizarova, M.
dc.contributor.author Dimova, I.
dc.contributor.author Toncheva, D.
dc.date.accessioned 2014-07-10T13:17:11Z
dc.date.available 2014-07-10T13:17:11Z
dc.date.issued 2012-06
dc.identifier.citation E. Hadzhiev, K. Alexandrova, M. Velizarova, I. Dimova and D. Toncheva. Association of 13q14 deletion with clinico-laboratory parameters in B-cell chronic lymphocytic leukemia (B-CLL) - Acta medica bulgarica , 39, 2012, No 2, 73-81. en_US
dc.identifier.issn 0324-1750
dc.identifier.uri http://hdl.handle.net/10861/547
dc.description Address for correspondence: Dr. Milena Velizarova Department of Clinical Laboratory and Clinical Immunology University Hospital “Alexandrovska” 1 G. Sofi yski str. 1431 Sofi a, Bulgaria tel.: +359 2 92 30 916 e-mail: mvelizarova@abv.bg en_US
dc.description.abstract A deletion of chromosome band 13q14 (13q-) detected by fl uorescence in situ hybridization (FISH) analysis is the single most common cytogenetic abnormality in patients with chronic lymphocytic leukemia (CLL). In our study we disccused the incidence of molecular-cytogenetic deletion of 13q14 marker in BCLL in order to determine the association of this aberration with clinical manifestation, laboratory parameters and poor disease prognosis. Patients with 13q14 aberrations were significantly older. They had ZAP (+) status, rapid disease progression and therapy dependency. A determination of 13q14 genetic abnormality should, therefore, be included in the investigations of the prognostic factors of B-cell chronic lymphocytic leukemia. en_US
dc.language.iso en en_US
dc.publisher Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia en_US
dc.subject deletion 13q14 (13q14 deletion), chronic lymphocytic leukemia, Fluorescence in situ hybridization, ZAP70. en_US
dc.title Association of 13q14 deletion with clinico-laboratory parameters in B-cell chronic lymphocytic leukemia (B-CLL) en_US
dc.type Article en_US


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  • Acta Medica Bulgarica
    Многопрофилно списание, излизащо само на английски език. Съдържа авторски статии от водещи български медицински специалисти, отразяващи върховите постижения на българската медицина наука и практика. Публикуват се материали, отразяващи резултати от експериментални проучвания, клиника и казуистика. Излиза 2 пъти годишно. ISSN:0324-1750

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