Central Medical Library - Sofia

Association between biochemical markers of bone turnover and markers in the estrogen receptor (ER) gene

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dc.contributor.author Ivanova, Zh.
dc.contributor.author Toshev, А.
dc.contributor.author Tsachev, K.
dc.date.accessioned 2013-09-26T08:44:47Z
dc.date.available 2013-09-26T08:44:47Z
dc.date.issued 2010-10
dc.identifier.citation Zh. Ivanova, А. Toshev and К. Tsachev. Association between biochemical markers of bone turnover and markers in the estrogen receptor (ER) gene - Acta Medica Bulgarica, 37, 2010, № 2, 3-14. en_US
dc.identifier.issn 0324-1750
dc.identifier.uri http://hdl.handle.net/10861/339
dc.description Address for correspondence: Zhivka Ivanova; Medical University – Sofia; Department of Biology; Zdrave 2 Str.; e-mail: jivka_iva@yahoo.com ; Mobile tel.: +359 887 760 503 en_US
dc.description.abstract Bone metabolism is characterized by two opposite activities: the formation of new bone by osteoblasts and the degradation of old bone by the osteoclasts. Osteoporosis is a disease in which subtle modifi cations of bone remodeling can result in a substantial loss of bone over a prolonged period of time. The needs for non-invasive techniques that can be applied more widely and repeated several times in a single patient explain the development of markers of bone turnover that are measured in blood and urine. The prognostic value of parameters as risk indexes for osteoporosis is not enough. This makes it possible to use genetic markers, which together with already existing risk indexes will improve the identifi cation of individuals with higher osteoporosis risk. The future development of genetic studies in osteoporosis will proceed in two major directions: identifi cation of further candidate genes, their interaction with each other and their application to defi ned diseases of bone metabolism. Abbreviations: (BMD) bone mineral density; (ER) estrogen receptor; (Pyr) pyridinoline; D-Pyr) deoxypyridinoline; (Cr) creatinine en_US
dc.language.iso en en_US
dc.publisher Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia en_US
dc.subject osteocalcin, deoxypyridinoline, estrogen receptor (ER), bone mineral density (BMD) en_US
dc.title Association between biochemical markers of bone turnover and markers in the estrogen receptor (ER) gene en_US
dc.type Article en_US


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  • Acta Medica Bulgarica
    Многопрофилно списание, излизащо само на английски език. Съдържа авторски статии от водещи български медицински специалисти, отразяващи върховите постижения на българската медицина наука и практика. Публикуват се материали, отразяващи резултати от експериментални проучвания, клиника и казуистика. Излиза 2 пъти годишно. ISSN:0324-1750

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