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Acute exogenic intoxications and level of the antioxidant selenium

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dc.contributor.author Tufkova, S.
dc.contributor.author Karaslavova, E.
dc.date.accessioned 2012-05-07T12:55:26Z
dc.date.available 2012-05-07T12:55:26Z
dc.date.issued 2008-06
dc.identifier.citation Tufkova, S. and E. Karaslavova. Acute exogenic intoxications and level of the antioxidant selenium - Acta Medica Bulgarica, 35, 2008, № 1, 25-31. en_US
dc.identifier.issn 0324-1750
dc.identifier.uri http://hdl.handle.net/10861/146
dc.description Address for correspondence: Dr. Stoilka Tufkova, Clinic of toxicology University Multiprofile Hospital “St. Georgi” – Plovdiv 032/ 602-406 0889/302-953 e-mail: tuffi_med@yahoo.com en_US
dc.description.abstract The human organism possesses a well built antioxidant defence system having as a purpose neutralizing the free radical processes. The antioxidant defence of the human organism can be divided in to three functional levels. Great importance is given to the second level represented by enzyme and non-enzyme components which defuse the already formed free radicals. Here a main representative is the microelement selenium. Aim of the study was tracing the level of selenium – a main element of the secondary antioxidant defence system of the human body in acute exogenic intoxications with cerebrotoxic medicaments, alcohol and heroin. The study is prospective and longitudinal comprising 118 patients with average and heavy degree of acute poisoning with cerebrotoxic medicaments (n=45), alcohol (n=40), heroin (n=33) and control (n=35). The clinical laboratory tests are made under definite standards of the clinical laboratory. Following statistical analyses are used: variational analysis/u-criterion for normal distribution, t-test of Student, dispersive analysis under the method of ANOVA test and non-parametric analysis. Our results show a statistically significant decrease of serum concentration of selenium in acute exogenic intoxications with cerebrotoxic medicaments, alcohol heroin – Р<0,001, without it correlating with the weight of the acute intoxication – Р>0,05. As a reliable marker for a complex estimate of the antioxidant system of humans is the tracing the serum level of selenium and its careful interpretation. en_US
dc.language.iso en en_US
dc.publisher Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia en_US
dc.subject selenium, enzyme and non-enzyme antioxidants, acute intoxications en_US
dc.title Acute exogenic intoxications and level of the antioxidant selenium en_US
dc.type Article en_US


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  • Acta Medica Bulgarica
    Многопрофилно списание, излизащо само на английски език. Съдържа авторски статии от водещи български медицински специалисти, отразяващи върховите постижения на българската медицина наука и практика. Публикуват се материали, отразяващи резултати от експериментални проучвания, клиника и казуистика. Излиза 2 пъти годишно. ISSN:0324-1750

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