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Arterial thrombosis in utero causing arm gangrene in the infant of a diabetic mother

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dc.contributor.author Zhekova, N.
dc.contributor.author Todorova, K.
dc.contributor.author Guenova, M.
dc.contributor.author Tsachev, K.
dc.date.accessioned 2012-05-03T11:56:31Z
dc.date.available 2012-05-03T11:56:31Z
dc.date.issued 2008-12
dc.identifier.citation Zhekova, N. , K. Todorova, M. Guenova and K. Tsachev. Arterial thrombosis in utero causing arm gangrene in the infant of a diabetic mother - Acta Medica Bulgarica, 35, 2008, № 2, 17-22. en_US
dc.identifier.issn 0324-1750
dc.identifier.uri http://hdl.handle.net/10861/135
dc.description Address for correspondence: Nelly Zhekova Department of Neonatology Specialized Hospital for Obstetrics and Gynecology “Maychin dom”, 2, “Zdrave” str. 1431 Sofia e-mail: nellyjekova@hotmail.com en_US
dc.description.abstract Gangrene of a limb presenting at birth is rare and has heterogenous etiology. Approximately 25% of the cases have been reported to occur in infants of diabetic mothers (IDMs). We report a newborn IDM with brachial artery thrombosis in utero and neonatal gangrene which necessitated a below elbow amputation at 5th day of life. The diagnosis of external left brachial artery thrombosis was made by Doppler sonography flow studies and was confirmed at autopsy. Despite the use of anticoagulants, the gangrene advanced and amputation of the necrotic forearm was performed. The postoperative period was complicated by mesenteric artery thrombosis with subsequent necrotizing enterocolitis, convulsions, septicemia and death. The reason for the increased tendency to develop thrombi in IDMs has not been elucidated. Changes in coagulation factors have been reported in newborn IDMs with poor control of maternal diabetes. Increased clotting and decreased fibrinolysis found in diabetics may lead to arterial thrombosis in IDMs in utero and postnatally. Use of anticoagulants in at-risk infants should be considered early to prevent further thrombosis and ischemic complications postnatally. en_US
dc.language.iso en en_US
dc.publisher Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia en_US
dc.subject arterial thrombosis in utero, newborn en_US
dc.title Arterial thrombosis in utero causing arm gangrene in the infant of a diabetic mother en_US
dc.type Article en_US


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  • Acta Medica Bulgarica
    Многопрофилно списание, излизащо само на английски език. Съдържа авторски статии от водещи български медицински специалисти, отразяващи върховите постижения на българската медицина наука и практика. Публикуват се материали, отразяващи резултати от експериментални проучвания, клиника и казуистика. Излиза 2 пъти годишно. ISSN:0324-1750

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